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. Author manuscript; available in PMC: 2013 Oct 28.

Published in final edited form as: Curr Top Med Chem. 2012;12(7):766–796. doi: 10.2174/156802612799984571

Table 6.

MbtA Inhibitors: Glycosyl Domain SAR


Compound, R =	K_i^app (μM)^a	MIC₉₉ (μM) (iron-deficient)	MIC₉₉ (μM) (iron-rich)
51	0.0066 ± 0.00015	0.39	1.56
74	0.0023 ± 0.0004	1.56	6.25
75	0.0035 ± 0.0004	25	100
76	0.0032 ± 0.0005	1.56	12.5
77	0.830 ± 0.078	> 200	> 200
78	0.061 ± 0.005	> 200	> 200
79	16.7 ± 0.5	> 200	> 200