Table 8.

Activities of NadE Inhibitors^a

compound	IC50 (μM)	MIC (μM)	MBC (μM)	MAC (μM)
117	insol.b	42	n.d.c	n.d.
118	25	15	10	19
119	63	155	n.d.	n.d.
120	22	20	40	42
121	58	40	n.d.	n.d.
122	10d	n.d.	n.d.	n.d.

^aSummary of in vitro activity against NadE (IC₅₀), MIC against M. tuberculosis H37Rv, minimum bactericidal concentration (MBC), minimum anaerobicidal concentration (MAC) defined as the concentration causing a 10-fold kill of bacteria in nonreplicating anaerobic culture after 7 days exposure.

^binsol., insoluble.

^cn.d., not determined.

^dIC₅₀ against NadE from Bacillus subtilus.