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. Author manuscript; available in PMC: 2013 Oct 28.
Published in final edited form as: Methods Mol Biol. 2012;808:10.1007/978-1-61779-373-8_21. doi: 10.1007/978-1-61779-373-8_21

Fig. 2.

Fig. 2

The structures of the aminoglycosides kanamycin A and tobramycin, their measured affinity to a mimic of the bacterial rRNA A-site (26) and the product of their modification by APH(3′)-IIIa. Note that kanamycin A is modified by APH(3′) because it contains a reactive hydroxyl group at the 3′ position, whereas tobramycin contains a hydrogen atom and is thus not susceptible to APH(3′) modification.