Table 1.

Genes with significant relevance to trophoblast differentiation and placental development.

Gene Symbol	Summary of significance (see text for details)
Fgf4	Maintenance of mouse TSC proliferation
Tgfb1	Maintenance of mouse TSC proliferation
Oct4 (Pou5f1)	ESC pluripotency transcription factor
Cdx2	Directs mouse trophoblast lineage selection and proliferation
Tead4	Trophoblast lineage selection upstream of Cdx2
Hippo	Indirect Tead4 regulator
Yap	Tead4 coactivator
Trim (ectodermin)	Nodal expression regulation
Nodal	TGFB1 regulator, trophoblast differentiation
Bmp4	Inner cell mass maintenance (mouse)
Gata3	Promotes trophoblast differentiation
Eomes	Mouse TSC maintenance
Esrrb	Mouse TSC maintenance
Ets2	Enhances Cdx2 action
Tcfap2c (tfap2c)	Trophoblast differentiation, enhances Cdx2 action
Elf5	Trophoblast lineage determination, Cdx2, Eomes interactions
Hand1	Trophoblast giant cell differentiation (mouse)
Mdfi	Trophoblast giant cell differentiation (mouse)
Mash2/Ascl2	Maintenance of mouse spongiotrophoblast
HASH2	Expressed in human cytotrophoblasts
Egfr	Maintenance of mouse spongiotrophoblast
Gcm1	Mouse syncytiotrophoblast differentiation
Eset	Methylation site-related silencing of trophoblast genes
Sox2	Pluripotency factor for ESC
Nanog	Pluripotency factor for ESC
Rex1	Inner cell mass marker
Fgf5	Epiblast marker
Klf4	Pluripotency factor for ESC
Lif	Maintenance of mouse ESC self-renewal