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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Cells Tissues Organs. 2013 Jun 15;198(1):10.1159/000348418. doi: 10.1159/000348418

Figure 1. Models for the Study of Cancer EMT and Metastasis, including the Chick Embryo Transplant Model.

Figure 1

A) There are at least four model systems, to analyze human tumor cell behaviors including in vitro culture, zebrafish and chick embryos, and adult mice. B) The chick embryo transplant model permits transplantation of human tumor cells into the neural crest microenvironment and visualization of cell behaviors in vivo in 3D using a teflon window into the egg that allows oxygen transfer to the embryo.