Table 1.

in vivo Models of Tumor Cell Behaviors

Animal Model	Tumor Type	Highlights/Methods	References
Chick embryo	mammalian tumor xenograft	static and dynamic imaging of cell cycle progression (CycleTrak) in migrating melanoma cells	Ridenour 2012
Zebrafish embryo	mammalian tumor xenograft	dynamic imaging of tumor neovascularization and evaluation of anti-angiogenic compounds	Zhao 2011
mouse	orthotopic mammalian tumor xenograft	mammary imaging window combined with photoswitchable fluorescent label provides extended intravital imaging	Kedrin 2008
mouse	mammalian tumor xenograft	skin fold chamber provides orthotopic intravital imaging of early stages of tumor invasion	Alexander 2008
mouse	mammalian tumor xenograft	simultaneous imaging of multiple fluorescent markers and collagen using multi-photon microscopy	Sahai 2005
rat	allograft	skin flap surgery to expose tumor for timelapse imaging	Wyckoff 2000