Table 4.
Summary of Published Evidence Comparing Life Participation Outcomes by RRT Modality and Study Characteristics
| HD vs. PD | HD vs. Tx | PD vs. Tx | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| No. of outcomes that | No. of outcomes that | No. of outcomes that | |||||||
|
| |||||||||
| Favors HD | Favors Neither | Favors PD | Favors HD | Favors Neither | Favors Tx | Favors PD | Favors Neither | Favors Tx | |
|
| |||||||||
|
Physical Function Domain
| |||||||||
| Study Design | |||||||||
| Randomized Trial | |||||||||
| Prospective Cohort | 5 | ||||||||
| Cross-Sectional | 3 | 26 | 6 | 8 | 17 | 7 | 14 | ||
| Pre-Post Transplant | 1 | ||||||||
|
| |||||||||
| Location | |||||||||
| US | 8 | 1 | 1 | ||||||
| Non-US | 3 | 23 | 7 | 8 | 17 | 7 | 13 | ||
|
| |||||||||
| Study Quality | |||||||||
| Appropriate Adjustment* | 12 | 2 | 2 | 3 | 3 | 2 | |||
| No/Minimal Adjustment* | 3 | 19 | 5 | 6 | 15 | 4 | 12 | ||
|
| |||||||||
| Publication Year | |||||||||
| 1980–1990 | 4 | 1 | 2 | 1 | 2 | ||||
| 1991–2000 | 6 | 3 | 1 | 4 | 2 | ||||
| 2001–2012 | 3 | 21 | 4 | 6 | 12 | 6 | 10 | ||
|
| |||||||||
| Outcome Measures | |||||||||
| SF-36 (Thai/UK/Greek) | 2 | 24 | 5 | 5 | 10 | 5 | 10 | ||
| CHEQ (Thai) | 1 | ||||||||
| Karnofsky | 1 | 1 | |||||||
| EQ-5D | 1 | ||||||||
| WHOQOL | 1 | 2 | 1 | ||||||
| Sickness Impact Profile | 1 | ||||||||
| Nottingham | 1 | ||||||||
| HD Stressor Scale | 1 | ||||||||
| Author-developed scales | 2 | 2 | 1 | 1 | 1 | ||||
| Other patient reports | 1 | 1 | 2 | 1 | 2 | ||||
| Physical assessments | 1 | 1 | |||||||
|
| |||||||||
|
Travel Domain
| |||||||||
| Study Design | |||||||||
| Randomized Trial | |||||||||
| Prospective Cohort | 1 | ||||||||
| Cross-Sectional | 1 | ||||||||
| Pre-Post Transplant | |||||||||
|
| |||||||||
| Location | |||||||||
| US | 1 | ||||||||
| Non-US | 1 | ||||||||
|
| |||||||||
| Study Quality | |||||||||
| Appropriate Adjustment* | 1 | ||||||||
| No/Minimal Adjustment* | 1 | ||||||||
|
| |||||||||
| Publication Year | |||||||||
| 1980–1990 | |||||||||
| 1991–2000 | |||||||||
| 2001–2012 | 1 | 1 | |||||||
|
| |||||||||
| Outcome Measures | |||||||||
| CHEQ (Thai) | 1 | 1 | |||||||
|
| |||||||||
|
Recreation Domain
| |||||||||
| Study Design | |||||||||
| Randomized Trial | |||||||||
| Prospective Cohort | 1 | ||||||||
| Cross-Sectional | 13 | 4 | 4 | 3 | 2 | 5 | |||
| Pre-Post Transplant | |||||||||
|
| |||||||||
| Location | |||||||||
| US | 5 | 1 | 2 | 2 | |||||
| Non-US | 9 | 3 | 4 | 1 | 2 | 3 | |||
|
| |||||||||
| Study Quality | |||||||||
| Appropriate Adjustment* | 4 | 1 | 1 | 1 | |||||
| No/Minimal Adjustment* | 10 | 4 | 3 | 3 | 1 | 4 | |||
|
| |||||||||
| Publication Year | |||||||||
| 1980–1990 | 1 | 2 | 3 | ||||||
| 1991–2000 | 2 | ||||||||
| 2001–2012 | 2 | 3 | 1 | 2 | 2 | ||||
|
| |||||||||
| Outcome Measures | |||||||||
| SF-36 (Greek) | 3 | 2 | 1 | 2 | 2 | ||||
| Sickness Impact Profile | 1 | 1 | |||||||
| Intrusiveness Ratings Scale | 1 | 1 | |||||||
| WHOQOL-100 | 1 | ||||||||
| Quality of Life Assessment Battery | 1 | ||||||||
| Author-developed scales | 1 | 1 | |||||||
|
| |||||||||
|
Freedom Domain
| |||||||||
| Study Design | |||||||||
| Randomized Trial | |||||||||
| Prospective Cohort | 1 | ||||||||
| Cross-Sectional | 1 | 5 | 1 | 4 | 4 | ||||
| Pre-Post Transplant | |||||||||
|
| |||||||||
| Location | |||||||||
| US | 3 | 1 | 2 | 2 | |||||
| Non-US | 1 | 3 | 2 | 2 | |||||
|
| |||||||||
| Study Quality | |||||||||
| Appropriate Adjustment* | 1 | ||||||||
| No/Minimal Adjustment* | 1 | 5 | 1 | 4 | 4 | ||||
|
| |||||||||
| Publication Year | |||||||||
| 1980–1990 | 2 | 2 | 2 | ||||||
| 1991–2000 | |||||||||
| 2001–2012 | 1 | 4 | 1 | 2 | 2 | ||||
|
| |||||||||
| Outcome Measures | |||||||||
| CHEQ (Thai) | 1 | 1 | |||||||
| EQ 5D | 2 | 1 | 1 | ||||||
| Renal Treatment Satisfaction | 1 | 1 | 1 | ||||||
| Index of Well-Being | 1 | 1 | 1 | ||||||
| Author-developed scales | 1 | 1 | 1 | 1 | |||||
|
| |||||||||
|
Work Domain
| |||||||||
| Study Design | |||||||||
| Randomized Trial | |||||||||
| Prospective Cohort | 1 | ||||||||
| Cross-Sectional | 2 | 8 | 2 | 6 | 5 | ||||
| Pre-Post Transplant | |||||||||
|
| |||||||||
| Location | |||||||||
| US | 2 | 4 | 1 | 3 | 3 | ||||
| Non-US | 5 | 1 | 3 | 2 | |||||
|
| |||||||||
| Study Quality: | |||||||||
| Appropriate Adjustment* | 1 | 2 | 1 | 1 | 1 | ||||
| No/Minimal Adjustment* | 1 | 7 | 1 | 5 | 4 | ||||
|
| |||||||||
| Publication Year | |||||||||
| 1980–1990 | 2 | 3 | 1 | 4 | 4 | ||||
| 1991–2000 | 1 | ||||||||
| 2001–2012 | 5 | 1 | 2 | 1 | |||||
|
| |||||||||
| Outcome Measures | |||||||||
| CHEQ (Thai) | 2 | ||||||||
| Sickness Impact Profile | 1 | 1 | 1 | ||||||
| KDQOL | 1 | 1 | 1 | 1 | |||||
| Intrusiveness Ratings Scale | 1 | 1 | 1 | ||||||
| WHOQOL-100 | 1 | ||||||||
| Author-developed scales | 1 | 1 | 1 | ||||||
| Other patient reports | 1 | 4 | 1 | 1 | 1 | ||||
RRT, renal replacement therapy; HD, hemodialysis; PD, peritoneal dialysis; Tx, transplantation; US, United States; SF-36, 36-Item Short-Form Health Survey; CHEQ, CHOICE (Choices for Healthy Outcomes in Caring for ESRD) Health Experience Questionnaire; WHOQOL, World Health Organization Quality of Life instrument; UK, United Kingdom; KDQOL, Kidney Disease Quality of Life scale;
*
For confounders.