Table-II.
The diagnostic characteristics of included studies in terms of EBV-DNA
| Study ID | TP | FP | FN | TN | Sensitivity(95% CI) | Specificity(95% CI) | +LR(95% CI) | -LR(95% CI) |
|---|---|---|---|---|---|---|---|---|
| Zhang 2012 | 27 | 10 | 13 | 40 | 0.68(0.51-0.81) | 0.80(0.66-0.90) | 3.38(1.86-6.12) | 0.41(0.26-0.65) |
| Zhu 2012 | 58 | 2 | 110 | 58 | 0.35(0.27-0.42) | 0.97(0.88-1.0) | 10.36(2.61-41.1) | 0.68(0.60-0.76) |
| Kong 2010 | 41 | 7 | 15 | 53 | 0.73(0.60-0.84) | 0.88(0.77-0.95) | 6.28(2.07-12.82) | 0.30(0.20-0.47) |
| Liao 2010 | 20 | 3 | 14 | 27 | 0.59(0.41-0.75) | 0.90(0.74-0.98) | 5.88(1.94-17.85) | 0.46(0.30-0.70) |
| Sun 2010 | 59 | 4 | 3 | 58 | 0.94(0.86-0.99) | 0.94(0.84-0.98) | 14.75(5.71-38.12) | 0.05(0.02-0.16) |
| Tan 2010 | 33 | 0 | 90 | 40 | 0.27(0.91-1.0) | 1.00(0.91-1.0) | 22.15(1.39-353.54) | 0.74(0.66-0.83) |
| Wai 2010 | 15 | 153 | 3 | 1028 | 0.83(0.57-0.96) | 0.87(0.85-0.89) | 6.43(4.99-8.29) | 0.19(0.07-0.54) |
| Feng 2009 | 45 | 1 | 20 | 28 | 0.69(0.57-0.80) | 0.97(0.82-0.99) | 20.08(2.91-138.69) | 0.32(0.22-0.46) |
| Luo 2009 | 110 | 9 | 50 | 67 | 0.69(0.61-0.76) | 0.88(0.79-0.94) | 5.81(3.12-10.82) | 0.35(0.28-0.45) |
| Chang 2008 | 127 | 9 | 29 | 255 | 0.81(0.74-0.87) | 0.97(0.94-0.98) | 23.88(12.51-45.58) | 0.19(0.14-0.27) |
| Sun 2008 | 65 | 6 | 3 | 84 | 0.96(0.88-0.99) | 0.93(0.86-0.98) | 14.34(6.61-31.11) | 0.05(0.02-0.14) |
| Ozyar 2007 | 24 | 10 | 0 | 19 | 1.00(0.86-1.00) | 0.66(0.46-0.82) | 2.8(1.71-4.57) | 0.03(0.01-0.48) |
| O 2007 | 17 | 7 | 5 | 79 | 0.77(0.55-0.92) | 0.92(0.84-0.97) | 9.49(4.51-20.0) | 0.25(0.11-0.54) |
| Leung 2004 | 132 | 4 | 7 | 174 | 0.95(0.90-0.98) | 0.98(0.94-0.99) | 42.26(16.02-111.44) | 0.05(0.03-0.11) |
| Fan 2004 | 64 | 29 | 1 | 39 | 0.99(0.92-1.0) | 0.57(0.45-0.69) | 2.31(1.75-3.05) | 0.03(0.01-0.19) |
| Shao 2004 | 138 | 12 | 9 | 66 | 0.94(0.88-0.97) | 0.85(0.75-0.92) | 6.10(3.62-10.29) | 0.07(0.04-0.14) |
| Krishna 2004 | 15 | 2 | 5 | 10 | 0.75(0.51-0.91) | 0.83(0.52-0.98) | 4.5(1.24-16.35) | 0.3(0.14-0.67) |
| Chan 2003 | 31 | 3 | 24 | 160 | 0.56(0.42-0.70) | 0.98(0.95-0.99) | 30.62(9.75-96.23) | 0.45(0.33-0.60) |
| Pratesi 2003 | 15 | 20 | 0 | 12 | 1.0(0.78-1.0) | 0.38(0.21-0.56) | 1.56(1.18-2.07) | 0.08(0.01-1.31) |
| Mai 2002 | 56 | 6 | 10 | 52 | 0.85(0.74-0.93) | 0.90(0.79-0.96) | 8.20(3.82-17.62) | 0.17(0.10-0.30) |
| Mutirangura 1998 | 13 | 29 | 0 | 82 | 1.0(0.75-0.82) | 0.74(0.65-0.82) | 3.66(2.64-5.07) | 0.05(0.003-0.74) |
| Shotelersuk 2000 | 83 | 63 | 10 | 67 | 0.89(0.81-0.94) | 0.52(0.43-0.60) | 1.84(1.52-2.23) | 0.21(0.11-0.38) |
| Lo 1999 | 55 | 3 | 2 | 40 | 0.97(0.88-0.95) | 0.93(0.81-0.99) | 13.83(4.64-41.24) | 0.04(0.01-0.15) |
| Pooled results | 1243 | 392 | 423 | 2538 | 0.75(0.72-0.76) | 0.87(0.85-0.88) | 6.98(4.50-10.83) | 0.18(0.11-0.29) |