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. Author manuscript; available in PMC: 2014 May 14.
Published in final edited form as: Biochemistry. 2013 May 2;52(19):10.1021/bi400165f. doi: 10.1021/bi400165f

Figure 6. Biochemical analysis of the interaction of Reelin with APP.

Figure 6

(A) Quantification of Aβ40, and Aβ42 (by ELISA) and CTF (by WB) in HEK293 assay with over-expression of APP751 (human, wild-type). (B) Reelin expression in CM of HEK293 cells co-transfected with APP751 (human, wild-type) and increased concentrations of Reelin cDNA. (C) Quantification of APPsα and APPsβ levels in response to increasing Reelin expression. (D) HEK293 cells were transfected with listed combinations of Reelin, APP, APOER2, and VLDLR, and co-IPs were performed for Reelin or else APP, APOER2, or VLDLR. Error bars represent s.e.m.; * p<.05, **p<.01, ***p<.001