. Author manuscript; available in PMC: 2014 May 14.

Published in final edited form as: Biochemistry. 2013 May 2;52(19):10.1021/bi400165f. doi: 10.1021/bi400165f

Table 1. Summary of candidate ligands tested in multiple APP shedding assays.

The magnitude of statistically significant changes (p<.05) in APPsα or APPsβ are represented by arrows. ↑ or ↓ < 25% change relative to control; ↑↑ or ↓↓ = 25-50% change; ↑↑↑ or ↓↓↓ > 50% change. An equals sign (=) represents no significance difference. Gray boxes represent conditions not determined.

Cell type	Ligand Source	APP	F-spondin		Reelin		β1 Integrin		Lingo1		CNTN2-Fc		Pancortin-1		Pancortin-3
Cell type	Ligand Source	APP	APPsα	APPsβ	APPsα	APPsβ	APPsα	APPsβ	APPsα	APPsβ	APPsα	APPsβ	APPsα	APPsβ	APPsα	APPsβ
HEK293	transient transfection	transient transfection	=	=	↓↓↓	↓↓	=	↑↑	↓↓	↓	=	=
HEK293	transient transfection	endogenous	↓	↓	↓	↓	↑	=	↓	↓↓	=	=	=	↓↓↓	=	=
primary rat cortical neurons	co-culture with HEK293 stables	endogenous	=		↓		=		↓		=		=		=
primary rat cortical neurons	CM from HEK293 stables	endogenous	=		=						=		=		=