Table 3.

NIA human disease gene sets enriched among genes identified as responsive to social conditions in PBMCs

Gene set	FDR-adjusted p value	Expected number of genes	Observed number of genes
Helicobacter infection	0.002	2.56	10
Periodontitis	0.002	3.53	12
Bacterial infections and mycoses	0.006	8.10	18
Disease progression	0.006	12.18	24
Stomatognathic diseases	0.006	5.53	14
Acute disease	0.010	5.29	13
Disease susceptibility	0.011	5.53	13
Female urogenital diseases and pregnancy complications	0.011	10.42	20
Immune system diseases	0.011	6.25	14
Skin and connective tissue diseases	0.013	11.46	21
Squamous cell carcinoma	0.032	6.41	13
Stomach neoplasms	0.034	5.13	11
Diabetes mellitus, Type 2	0.050	16.59	25
Nutritional and metabolic diseases	0.050	28.86	39

Enrichments were calculated using the hypergeometric test implemented in [89] for categories with a minimum of 10 genes in the data set (the union set of genes identified as social environmentally responsive in [47, 50, 77, 82]). FDRs were calculated following the method of [155]