Table 1.
DMBA induced cancer incidence in Cx43+/− and Cx43+/+ mice divided by topography and tumor histopathological classification.
| Cancer | Cx43+/− (n = 75) | Cx43+/+ (n = 60) | ||
|---|---|---|---|---|
| Number of tumors | % | Number of tumors | % | |
| Mammary gland | n = 36 | 48.00 | n = 27 | 45.00 |
| Adenoacanthoma | 20 | 47.62 | 10 | 34.48 |
| Adenocarcinoma type A | 5 | 11.90 | 4 | 13.79 |
| Adenocarcinoma type C | 1 | 2.38 | 0 | 0.00 |
| Carcinosarcoma | 0 | 0.00 | 0 | 0.00 |
| Cystic adenocarcinoma | 12 | 28.57 | 12 | 41.38 |
| Fibrosarcoma | 1 | 2.38 | 0 | 0.00 |
| undifferentiated type | 1 | 2.38 | 0 | 0.00 |
| Organoid | 2 | 4.76 | 0 | 0.00 |
| Total | 42 | 100.00 | 29 | 100.00 |
|
| ||||
| Digestive tract | n = 20 | 26.67 | n = 16 | 26.67 |
| Squamous cell carcinoma | 20 | 95.24 | 16 | 5.52 |
| Gastric adenocarcinoma | 1 | 47.61 | 0 | 0.00 |
| Total | 21 | 100.00 | 16 | 100.00 |
|
| ||||
| Lymphoid tissue | n = 32 | 42.67 | n = 26 | 43.33 |
| Lymphoma | 32 | 100.00 | 26 | 100.00 |
| Total | 32 | 100.00 | 26 | 100.00 |
|
| ||||
| Skin | n = 10 | 13.33 | n = 9 | 15.00 |
| Squamous cell carcinoma | 10 | 100.00 | 9 | 100.00 |
| Total | 10 | 100.00 | 9 | 100.00 |
|
| ||||
| Lung | n = 21 | 28.00 | n = 7 | 11.66 |
| Papillary adenocarcinoma | 21 | 95.45 | 7 | 100.00 |
| Bronchial carcinoma | 1 | 4.45 | 0 | 0.00 |
| Total | 22 | 100.00 | 7 | 100.00 |
|
| ||||
| Ovary | n = 10 | 13.33 | n = 3 | 5.00 |
| Granulosa cell carcinoma | 10 | 100.00 | 3 | 100.00 |
| Total | 10 | 100.00 | 3 | 100.00 |
|
| ||||
| Total | 137 | 90 | ||
| Number of cancer histological types per animal | 1.83 | 1.50 | ||
Note: there are more tumors than mice in the experiment because some animals developed more than one type of cancer in the same or different organs.