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. 2013 Nov 10;19(14):1619–1633. doi: 10.1089/ars.2012.5089

FIG. 2.

FIG. 2.

Equal efficacy of Hp phenotype-specified therapeutics against Hb-induced hypertension. (A) % change (Δ) in MAP from baseline values to 180 mg Hb is shown as control (gray circles), Hp1-1 (open circles), and Hp2-2 (dark circles) groups (n=5/group). In the Hp1-1 and Hp2-2 groups, each Hp phenotype was administered in gram equivalent dose 10 min after the Hb infusion. Animals were monitored continuously for 80 min. (B) % change (Δ) maximum MAP was determined as the change from maximum Hb-induced MAP response to MAP after the Hp infusion (15 min). (C) Area under the MAP curve (AUC) was determined by the linear trapezoidal rule for determining AUC in the interval 0–80 min using individual data plotted in (A). All data are representative of mean values±SE. Statistical significance was set at p<0.05. Systolic and diastolic blood pressures were measured using a Gould pressure transducer with data acquisition record using a BioPak data acquisition system and AcqKnowledge software for data analysis and MAP calculation. MAP, mean arterial blood pressure; SE, standard error.