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. 2013 Nov 1;23(21):6019–6024. doi: 10.1016/j.bmcl.2013.08.010

Table 1.

Pyrazole N-substituent variations

Compound R1 R2 PfCDPK1 IC50 (μM) Pf EC50a (μM) Compound R1 R2 PfCDPK1 IC50 (μM) Pf EC50a (μM)
2 — — 0.013 0.400 9 graphic file with name fx2.gif H 0.546 nt
6 graphic file with name fx3.gif H 1.98 nt 10 graphic file with name fx4.gif H 0.071 0.999
7 graphic file with name fx5.gif H 1.50 nt 11 graphic file with name fx6.gif Me 3.61 nt
8 graphic file with name fx7.gif H 0.480 nt 12 graphic file with name fx8.gif H 0.043 0.985
a

nt = not tested.