Figure 2.

Current-Voltage Relations for NvNa_v2.1 Mutants in Na⁺ and K⁺ Single Ion Solutions and Relative Permeabilities

Currents were elicited for 200 ms from −95 up to 70 mV from a holding potential of −100 mV.

(A–D) Current-voltage relations of representative oocytes expressing NvNa_v2.1 (A), NvNa_v2.1^DEKA (B), NvNa_v2.1^DKEA (C), or NvNa_v2.1^{NvNav2.5(p−loops)} (D). Circles: Na⁺ single ion solution; squares: K⁺ single ion solution. The relative ion permeability was calculated from the difference in reversal potential between K⁺ and Na⁺ single ion solutions of identical concentrations (see Experimental Procedures). The values provided are the mean ± SEM of n cells. The protonation state of each SF residue is indicated in parentheses, with x designating an uncharged residue.

See also Figure S2.