Figure S2.

Currents Mediated by Channel Mutants NvNa_v2.1^{NvNav2.5(p−loops DEEA)} and NvNa_v2.1^{NvNav2.5(p−loops DEKA)} Expressed in Oocytes, Related to Figure 3

(A) Currents elicited by 500 ms depolarizing pulses from −75 to 50 mV mediated by NvNa_v2.1^{NvNav2.5(p−loops DEEA)} in ND96 bath solution. Note the large tail currents upon returning to the −80 mV holding potential.

(B) Inward currents elicited by 200 ms depolarizing pulses from −75 to 50 mV mediated by NvNa_v2.1^{NvNav2.5(p−loops DEKA)} in ND96 bath solution. Note the absence of tail currents (see inset). The E_rev value obtained for the current-voltage relations is 19.1 ± 1.6 (n = 6). Each point represents mean ± SEM of n cells.

(C) Currents elicited by 200 ms depolarizing pulses from −90 to 50 mV mediated by NvNa_v2.1^{NvNav2.5(p−loops DEKA)} in K⁺ single ion bath solution.