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CYP1A1 but not CYP1B1 mRNA expression, is markedly enhanced in VHL defective cells. RCC4-VHL (□) and RCC4 cells (■) were incubated with DMSO or 0.1 μM BaP for 18 h. RNA was isolated and mRNA levels were measured of (A) CYP1A1 and (B) CYP1B1. Data (n = 4) are presented as mean fold change ± SE (**P < 0.01).
