Figure 9.

Model Describing the Three Variants of Sequential Protein Interactions Leading to Gc Recruitment to ERES and Subsequent Exit via COPII Vesicles to Golgi, Where Bunyavirus Particle Assembly Primarily Takes Place.

In (A), Gc first becomes engaged in an interaction with N/RNPs prior to the interaction with Gn and subsequent ER exit via ERES; alternatively, Gc and Gn first heterodimerize. Next, although already ER exit competent, they immediately interact with N/RNPs to exit ER as a large structural viral protein complex (B) or only interact with RNPs at the Golgi interface while having transported there first as a Gn-Gc heterodimer (C).

[See online article for color version of this figure.]