Table 2.

Performance of Single and Biomarker Combinations in Discriminating Sporadic Creutzfeldt-Jakob Disease from All Dementias, Including Alzheimer's Disease

	Single biomarkers			Biomarkers combinations
Biomarker	Frx	t-Tf	t-tau	Frx & t-Tf	Frx & t-tau	t-Tf & t-tau	Frx & t-Tf & t-tau
Area under ROC (95% CI)	0.75 (0.67–0.84)	0.89 (0.84–0.95)	0.82 (0.74–0.90)	0.94 (0.89–0.98)	0.83 (0.75–0.90)	0.93 (0.88–0.97)	0.95 (0.92–0.99)
Sensitivity (95% CI)	85.7 (76.4–91.9)	87.9 (79–93.5)	87.9 (79–93.5)	86.8 (77.7–92.7)	85.7 (76.4–91.9)	85.7 (76.4–91.9)	90.1 (81.6–95.1)
Specificity (95% CI)	49.1 (35.3–63)	71.7 (57.4–82.8)	69.8 (55.5–81.3)	92.5 (80.9–97.6)	66.0 (51.6–78.1)	83.0 (69.7–91.5)	90.6 (78.6–96.5)
Positive LR (95% CI)	1.7 (1.3–2.2)	3.1 (2–4.8)	2.9 (1.9–4.4)	11.5 (4.5–29.6)	2.5 (1.7–3.7)	5 (2.8–9.2)	9.6 (4.1–22.1)
Negative LR (95% CI)	0.3 (0.2–0.5)	0.2 (0.1–0.3)	0.2 (0.1–0.3)	0.1 (0.1–0.2)	0.2 (0.1–0.4)	0.2 (0.1–0.3)	0.1 (0.1–0.2)
PPV (%) (95% CI)	74.30 (64.7–82.1)	84.2 (75–90.6)	83.3 (74–89.9)	95.2 (87.5–98.4)	81.3 (71.7–88.2)	89.7 (80.8–94.9)	94.3 (86.5–97.9)
NPV (%) (95% CI)	66.70 (49.7–80.4)	77.60 (63–87.8)	77.1 (62.3–87.5)	80.3 (67.8–89)	72.90 (57.9–84.3)	77.20 (63.8–86.8)	84.2 (71.6–92.1)
AIC	1.16	0.79	1.18	0.62	1.07	0.68	0.57
Accuracy	72.2	81.9	81.3	88.9	78.5	84.7	90.3

CJD (n=91) vs. DM (n=53).

Samples with all three biomarker values were used for this analysis.