[Table/Fig-2]:

Clinical Characteristics of the patients infected with OXA -48 producing isolates

Characteristics	Patient -1	Patient -2
Isolate Number	MS 2218	MS2287
Isolate	Klebsiella pneumoniae	Citrobacter freundii
Age /sex	73 years, female	56 years ,male
Hospital location	ICU	ICU
Admitting unit	Cardiology	Neurosurgery
Underlying disease	Coronary heart disease	Road traffic accident
Co-morbid conditions	Diabetes mellitus	none
Days in hospital	35 days	45days
Surgical procedures ,if any	Coronary artery bypass grafting	Craniotomy
Anti–microbials used prior to detection of OXA-181	Cefoperazone- sulbactam, vancomycin	Ceftriaxone, cefoperazone -sulbactam, amikacin, imipenem, metronidazole
Indwelling devices	Internal jugular venous catheter, peripheral venous line, urinary catheter	Internal jugular venous catheter, peripheral venous line, urinary catheter
Mechanical ventilation	Intubated	Intubated
Outcome	Recovered	Expired
Source specimen	Blood	Urine
MIC –IMP mg/L	128	32
MIC –MEM mg/L	64	16
MHT	Positive	Positive
ESBL screen test	Positive	Positive
Carbapenemase	OXA-48/OXA-181	OXA-48/OXA-181
Anti–microbial susceptibility profile Susceptible to	Colistin and tigecycline	Colistin and tigecycline
Anti–microbial susceptibility profile Resistant to	amikacin, ciprofloxacin,aztreonam, piperacillin-tazobactam and ceftazidime	amikacin, ciprofloxacin, aztreonam, piperacillin-tazobactam and ceftazidime