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Interleukin-33 (IL-33) exacerbates colitis via IL-4. Groups of wild-type (WT) and IL-4−/− mice were injected with IL-33 as above. (a) Diarrhoea score, (b) colon length and histological score in the mice were determined as described in the Materials and methods. (c) The levels of serum cytokine were measured by luminex. Data are representative of two experiments, n = 5 mice per group, *P < 0·05, **P < 0·01 compared with the PBS group.
