Figure 6.
Effects of continuous exposure to indomethacin on eosinophil migration in response to prostaglandin D2 (PGD2) and eotaxin. Indomethacin was added to both upper and lower chambers. Migration to PGD2 (a), eotaxin (b) and PGD2/eotaxin (c) was assessed. Chemokinesis (eosinophil migration to medium, open column) markedly increased under exposure to indomethacin. On the other hand, eosinophil migration to PGD2 significantly decreased, and eotaxin-induced migration was enhanced at high doses of indomethacin along with increased chemokinesis. (c) Eosinophil migration to PGD2/eotaxin was dose-dependently suppressed under continuous exposure to indomethacin. *P < 0·05. Representative results of at least three independent experiments are shown.