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. 2013 Aug 12;140(1):111–122. doi: 10.1111/imm.12122

Figure 2.

Figure 2

Significantly up-regulated genes in the caeca and colons of Clostridium difficile-infected (CDI) mice. Custom-made RT-PCR cards were used to evaluate gene expression levels in the caeca (n = 12 pairs) and colons (n = 12 pairs) of untreated and CDI mice from three sets of experiments. (a) significantly up-regulated chemokines in the caeca and colons of CDI mice; (b) pro-inflammatory cytokines that had significantly higher expression levels in these tissues; (c) significant up-regulation of Il22 and anti-microbial peptide mRNAs. Each bar represents the mean ± SEM of the relative expression of the depicted gene. ⋆ denotes a significant difference in expression levels between untreated and CDI mice, i.e. false discovery rate ≤ 0.05. The up-regulation of Reg3g in the colon did not reach statistical significance.