Table 3.
Summary of Zimmerman Program plasma VWF levels in type 2 VWD subjects.
| Type 2A (n=26) | Type 2B (n=11) | Type 2M (n=10) | Type 2N (n=7) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Mean | Observed range | Mean | Observed range | Mean | Observed range | Mean | Observed range | |
| VWF:Ag | 30 | 8–86 | 31 | 17–52 | 35 | 10–88 | 85 | 51–135 |
| VWF:RCo* | 8 | <10–48 | 16 | <10–39 | 16 | <10–56 | 86 | 51–148 |
| VWF:RCo/VWF:Ag ratio* | 0.34 | 0–1 | 0.55 | 0–1.11 | 0.68 | 0–1.49 | 1.08 | 0.86–1.37 |
| FVIII | 45 | 19–92 | 37 | 19–55 | 63 | 27–145 | 28 | 7–55 |
| VWF:CB (type III) | 16 | 0–72 | 15 | 4–39 | 38 | 11–111 | 90 | 54–146 |
| VWF:CB/VWF:Ag ratio (type III) | 0.38 | 0–1.02 | 0.40 | 0.19–0.81 | 1.08 | 0.82–1.32 | 1.05 | 0.83–1.18 |
| VWF:CB (type I) | 23 | 0–104 | 22 | 11–37 | 45 | 11–130 | 133 | 71–387 |
| VWF:CB/VWF:Ag ratio (type I) | 0.62 | 0–1.38 | 0.70 | 0.48–1.29 | 1.22 | 0.66–1.67 | 1.47 | 0.79–2.87 |
| VWF:CB (type VI) | 20 | 0–110 | 17 | 3–37 | 33 | 0–100 | 89 | 61–128 |
| VWF:CB/VWF:Ag ratio (type VI) | 0.50 | 0–1.39 | 0.47 | 0.18–0.84 | 0.89 | 0–1.33 | 1.08 | 0.95–1.20 |
*
For 16 type 2A subjects, two type 2B subjects and one type 2M subject with VWF:RCo <10 IU/dL, an arbitrary value of 5 IU/dL was assigned for calculation purposes. Geometric means are given for VWF:Ag, VWF:RCo, FVIII, and VWF:CB and arithmetic means for the VWF:CB/VWF:Ag ratios. Data are given in IU/dL with the exception of type VI collagen binding, which was normalized to an international standard and is given in U/dL.