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. Author manuscript; available in PMC: 2014 Oct 7.
Published in final edited form as: Mol Pharm. 2013 Aug 30;10(10):10.1021/mp4003688. doi: 10.1021/mp4003688

Figure 5.

Figure 5

In vivo antitumor efficacy of CDDP-loaded nanogels and Pt accumulation in A2780 human ovarian cancer xenograft-bearing female nude mice. a) Tumor growth, b) body weight (calculated as body weight subtract tumor) and c) survival time after administration of 5% dextrose (1, control), CDDP alone (2), nanogel/CDDP (3), LHRH-nanogel/CDDP (4) at a dose of 4 mg CDDP equivalents/kg body weight every 4th day. d) Concentration of Pt in organs and tumor by ICP-MS. Mice were sacrificed in a week after receiving four i.v. injections of free CDDP, nanogel/CDDP and LHRH-nanogel/ CDDP. Data are mean ± SEM, n = 7-8, *p < 0.05, **p < 0.01, NS is not significant.