. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Mol Cell Neurosci. 2013 Jul 31;56:10.1016/j.mcn.2013.07.010. doi: 10.1016/j.mcn.2013.07.010

Table 1. Relationship between activity, GluA2 trafficking and AMPAR regulatory protein expression in the retina.

Table summarizes results demonstrating the effects of activity on AMPAR regulatory protein expression (top) and AMPAR regulatory protein expression and GluA2 trafficking (bottom) in the retina. Up and down arrows indicate an increase and decrease in protein expression or extent of GluA2 trafficking, respectively.

Effect of Activity on Protein Expression
	Dark/Light	−Activity/+Activity
Surface GluA2	⬇
GRIP expression	⬇	⬇
PICK1 expression	⬆	⬆
Arc expression	⬆	⬆
GRIP bound GluA2	⬇

Constitutive Endocytosis Following siRNA
	−Activity	+Activity
No siRNA	⬆	⬇
GRIP siRNA	⚌	⬆
PICK1 siRNA	⬇	⚌
Arc siRNA	⬇	⚌