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. 2013 Oct 25;123(11):4888–4899. doi: 10.1172/JCI66218

Figure 7. AMPK activation reverses diabetes-induced regulation of mitochondrial respiratory chain function, mtDNA deletion, and PDH phosphorylation.

Figure 7

(A) Total mitochondrial content per kidney protein (mg/g), (B) complex I activity, (C) complex III activity, (D) complex IV activity, (E) quantitative analysis of PDH phosphorylation, and (F) D17 mtDNA deletion in kidney DNA measured in control, STZ-diabetic, and STZ-diabetic mice treated with AICAR (DM-AICAR). (n ≥ 6 per group, *P < 0.05 vs. control; **P < 0.05 vs. corresponding diabetic group).