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. 2013 Oct 15;123(11):4769–4780. doi: 10.1172/JCI70528

Figure 7. Genetic and pharmacologic blockade of spontaneous scratching behavior in BRAFNav1.8 mice.

Figure 7

(A) Spontaneous scratching of BRAFNav1.8 mice was significantly attenuated in Grp–/– or Grpr KO background and in mice treated with i.t. bombesin-saporin (BB-sap). *P < 0.05, **P < 0.01, 1-way ANOVA followed by post-hoc analysis, wild-type vs. BRAFNav1.8 mice. (B) GRP blocker 77427 (i.p.) significantly reduced scratching elicited by GRP (i.t.) or CQ (i.d.) in wild-type mice but not in Grp–/– or Grpr KO mice. (C) Spontaneous scratching of BRAFNav1.8 mice was significantly reduced by i.p. injection of 77427 or the H1R antagonist chlorpheniramine (CRP) or i.t. injection of a MEK inhibitor, U0126. (D) Scratching behavior of mice induced by i.d. CQ and histamine did not differ after i.t. U0126. *P < 0.05, **P < 0.01, 2-tailed t test vs. vehicle controls. n = 6–10.