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. 2013 Oct 1;123(11):4695–4705. doi: 10.1172/JCI71543

Figure 5. Aging mutant CAPS mice on IL-18R knockout background develop systemic inflammation.

Figure 5

(A) Extended survival and (B) growth of MWS Il18r–/–, Il18r–/–, MWS Il1r–/–, and Il1r–/– mice (n = 7–46 for survival and 1–38 for growth, mean ± SEM). Statistical significance was tested by log-rank (Mantel-Cox) comparison. (C) Complete peripheral blood counts for MWS Il1r–/– and Il18r–/– mice at 16 weeks of age (n ≥ 3 mice; each graph point represents 1 mouse, with mean identified by horizontal bar). (D) Spleens from MWS Il18r–/–, Il18r–/–, MWS Il1r–/–, Il11r–/–, and WT littermates were weighed at 8 or 15 weeks (n = 3–12 mice; each graph point represents 1 mouse, with mean identified by horizontal bar). *P < 0.05, **P < 0.005, by Student’s t test. WBC, white blood cells; RBC, red blood cells; ANC, absolute neutrophil count.