Table 1. Clinical and demographic variables for remitter and non-remitter bipolar depressed groups.
| Remitters | Non-remitters | P value | |
|---|---|---|---|
| Age in years | 41.0 (10.1) | 36.9 (8.0) | 0.14a |
| Sex (% female) | 66.7 | 56.0 | 0.70b |
| HAMD baseline | 28.9 (7.4) | 27.2 (6.9) | 0.53a |
| HAMD 3 month | 5.8 (2.8) | 20.6 (7.3) | 1.71 e-6 |
| YMRS baseline | 5.9 (7.5) | 8.0 (8.5) | 0.52a |
| YMRS 3 month | 1.9 (3.4) | 3.1 (3.4) | 0.40a |
| Medication Status (%AE) | 77.8 | 64.0 | 0.68b |
| Bipolar subtype (% Bipolar I) | 44.4 | 76.0 | 0.40 |
| 5HT1AR CC polymorphism (%) | 33.3 | 24.0 | |
| 5HT1AR CG polymorphism (%) | 44.4 | 48.0 | |
| 5HT1AR GG polymorphism (%) | 22.2 | 28.0 | 0.31c |
Values for age, HAMD and YMRS are listed as group means with standard deviations in parentheses. HAMD: Hamilton Depression Rating Scale value. YMRS: Young Mania Rating Scale value. 5HT1AR polymorphism: Serotonin 1A receptor promoter C(-1019)G biallelic genotype. Bipolar Subtype: Percentage of bipolar patients with a bipolar I subtype diagnosis. AE: Percentage of patients who have been exposed to antidepressants recently (see methods).
a
Calculated with two tailed t test,
b
Calculated with Fisher's exact test.
c
Calculated using Fisher's exact test comparing count data for the three polymorphisms between the two groups