Figure 2.

Left: a prototypical 2:2 β-hairpin mimetic (residues 1–12 with a D-Pro-l-Pro template); middle and right: a model β-hairpin (yel-low) superimposed (the C(β) atoms of the side chains shown were used as the anchor points for the superimposition) on the Rev helical peptide (cyan). The β-hairpin backbone can be used as a scaffold to pre-organize side chains in a geometry similar to that seen in the helical peptide.