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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Int J Cancer. 2012 Nov 23;132(10):10.1002/ijc.27919. doi: 10.1002/ijc.27919

Table 2.

Cytotoxicity, receptor number, and internalization of NZ-1-(scdsFv)-PE38KDEL on brain tumor cells*

Xenograft NZ-1-(scdsFv)-PE38KDEL IC50 ng/mL Number of podoplanin molecules per cell Percent Internalized
D08-0695MG >1000 1.0 × 103 ND
D08-0537MG >1000 6.9 × 102 ND
D2159MG 1.6 ± 1.2 3.4 × 106 80%
D08-0308MG 3.3 ± 2.0 1.1 × 105 87%
D08-0493MG 2.7 ± 1.7 6.1 × 107 42%
D283MED 9.7 ± 4.0 7.3 × 103 ND
D425MED 26.7 ± 4.0 6.5 × 104 93%
DAOY 29.0 ± 14.4 1.3 × 106 21%
*

Cytotoxicity data are given as an IC50 value, the concentration of immunotoxin that causes a 50% inhibition of protein synthesis after a 20-h incubation with immunotoxin.

ND: Not determined.