Figure 6.

Model of p47–p97 as a physiological complex. Fitting of a model based on our crystal structure with six p47 C molecules bound to the periphery of the p97 ND1 hexamer onto a cryo-EM projection map of the full-length p97–p47 complex (figure adapted from Rouiller et al, 2000). Note the remarkable agreement in both dimensions and overall fit of the ND1–p47 C structure. An arrow indicates the position of the p47 C domain bound to the ND1 hexamer, which fits well in density attributed to p47 by Rouiller et al (2000).