Table II. .
IPA parameters at final-extent 20 µM ADP-induced and collagen-induced aggregation (Study B).
| Parameter | Ticagrelor 200 mg bida/aspirin 75 mg qd (n = 16) | Clopidogrel 300 mg load, 75 mg qdb/aspirin 75 mg qd (n = 16) | Difference (ticagrelor – clopidogrel) (95% CI) | p-value |
|---|---|---|---|---|
| ADP-induced | ||||
| IPAmax (%) | 99.5 (2) | 88.3 (18) | 11.1 (3.4–18.8) | 0.0077 |
| TIPAmax (h) | 0.0 (0.0–4.0) | 4.0 (0.0–12.0) | NA | NA |
| AUEC0–12 (%·h) | 1163 (10) | 1002 (25) | 161 (40–283) | 0.0129 |
| AUEC0–24 (%·h) | 2234 (18) | 1888 (32) | 346 (38–653) | 0.0302 |
| Collagen-induced | ||||
| IPAmax (%) | 83.0 (16) | 74.1 (18.4) | 8.7 (3.9–13.6) | 0.0017 |
| TIPAmax (h) | 4.0 (2–24) | 4.0 (2–12) | NA | NA |
| AUEC0–12 (%·h) | 939 (18) | 836 (19) | 103 (45–161) | 0.0019 |
| AUEC0–24 (%·h) | 1785 (18) | 1566 (20) | 219 (92–346) | 0.0023 |
Data are mean (coefficient of variation %) for IPAmax and AUEC; median (range) for TIPAmax. ADP = adenosine diphosphate; AUEC0–12, AUEC0–24 area under the effect curve of IPA from 0–12 hours and 0–24 hours, respectively; CI = confidence interval; IPA = inhibition of platelet aggregation; IPAmax = maximum IPA; TIPAmax = time to IPAmax. p-values are for ticagrelor/aspirin comparison to clopidogrel/aspirin dosing using ANOVA.
a
200 mg bid for 5 days then a single 200 mg dose for one day.
b
300 mg for one day then 75 mg qd for 5 days.