Table 3.
Summary of participant demographics.
| Demographic | Statistic | Single dose study (n = 6 per dose)
|
Repeated dose studya (n = 12 per dose)
|
||||
|---|---|---|---|---|---|---|---|
| 140 mg/kg body weight | 357 mg/kg body weight | 714 mg/kg body weight | 420 mg/kg body weight/day | 1071 mg/kg body weight/day | 2142 mg/kg body weight/day | ||
| Age (years) | Mean (SD) | 34.5 (8.02) | 32.3 (9.31) | 32.0 (8.72) | 33.3 (7.20) | 30.7 (6.10) | 35.5 (7.68) |
| Minimum | 23 | 18 | 23 | 19 | 18 | 20 | |
| Maximum | 45 | 43 | 45 | 41 | 38 | 45 | |
| BMI (kg/m2) | Mean (SD) | 26.4 (1.91) | 26.0 (2.40) | 25.4 (2.71) | 26.7 (2.87) | 26.1 (2.19) | 27.0 (2.26) |
| Minimum | 24.0 | 21.6 | 22.2 | 21.3 | 21.9 | 22.2 | |
| Maximum | 29.4 | 27.9 | 28.4 | 29.7 | 29.2 | 29.7 | |
| Height (cm) | Mean (SD) | 167.6 (9.43) | 164.1 (5.97) | 168.1 (8.58) | 168.8 (11.57) | 168.0 (7.23) | 169.3 (8.35) |
| Minimum | 156.6 | 157.1 | 156.5 | 149.7 | 148.2 | 155.4 | |
| Maximum | 180.3 | 174.3 | 182.5 | 188.3 | 174.1 | 188.0 | |
| Weight (kg) | Mean (SD) | 74.7 (12.19) | 70.3 (9.59) | 71.6 (8.96) | 76.1 (10.67) | 73.8 (9.53) | 77.7 (10.82) |
| Minimum | 58.9 | 53.3 | 60.6 | 55.5 | 57.0 | 63.3 | |
| Maximum | 88.7 | 82.8 | 85.3 | 93.2 | 88.2 | 101.8 | |
| Gender | Female | 3 (50.0%) | 4 (66.7%) | 3 (50.0%) | 6 (50.0%) | 6 (50.0%) | 6 (50.0%) |
| Male | 3 (50.0%) | 2 (33.3%) | 3 (50.0%) | 6 (50.0%) | 6 (50.0%) | 6 (50.0%) | |
| Race | Mixedb | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (8.3%) | 0 (0.0%) |
| Black/African American | 2 (33.3%) | 1 (16.7%) | 0 (0.0%) | 6 (50.0%) | 3 (25.0%) | 2 (16.7%) | |
| White | 4 (66.7%) | 5 (83.3%) | 6 (100.0%) | 6 (50.0%) | 8 (66.7%) | 10 (83.3%) | |
BMI = body mass index; SD = standard deviation.
A
Ketone monoesters were administered as three divided doses of 140 mg/kg bw, 357 mg/kg bw, and 714 mg/kg bw over the course of the day.
b
Mixed race refers to combination of American Indian/Alaska Native, Black/African America, and White.