Table 1.
Serum biochemical findings in disorders of phosphate homeostasis and tissue mineralization
| Parameter | Hypophosphataemia |
Hyperphosphataemia |
Normophosphataemia | ||
|---|---|---|---|---|---|
| FGF23- dependent |
FGF23- independent |
FGF23- deficient |
FGF23- resistant |
||
| Acquired | TIO, post-renal transplant | Post hepatectomy | NA | NA | NA |
| Inherited | XLH, ADHR, ARHP, OGD, OSD, FD/MAS, NF1+2 | HHRH | HFTC1, HFTC2 | HFTC3 | pulmonary alveolar microlithiasis, NFTC |
| S-Ca | NL | NL | NL to high | NL to high | NL |
| S-PO4 | low | low | high | high | NL |
| S-PTH | NL to high | NL to low | NL to low | NL to high | NL |
| S-1,25(OH)2D | NL to LOW | HIGH | high | high | NL |
| S-FGF23 | NL to HIGH | low | low | high | NL |
| U-PO4 | HIGH | high | low | low | NL |
| U-Ca | NL to LOW | high | NL to HIGH | NL to HIGH | NL |
| Current treatment | phosphate and alfacalcidol or calcitriol | phosphate replacement only | phosphate binders, acetazolamide, PTH | phosphate binders, acetazolamide, PTH | supportive measures |