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. Author manuscript; available in PMC: 2013 Oct 28.
Published in final edited form as: N Engl J Med. 2008 Dec 3;359(25):10.1056/NEJMoa0806450. doi: 10.1056/NEJMoa0806450

Figure 2. Association of Oversulfated Chondroitin Sulfate (OSCS) in Unfractionated Heparin with Induction of Kallikrein Activity.

Figure 2

Thirteen samples of heparin, including one sample of non–clinical-grade heparin (control heparin 1), representing both suspect heparin lots and control lots, were analyzed in a blinded fashion for both the presence of OSCS and the ability to activate kallikrein. The presence of OSCS was detected and quantified as described elsewhere.6 The amidolytic activity of kallikrein was assessed at various concentrations of heparin, as indicated. Lots A through D and F through J contained OSCS. Samples from Lot E, as well as controls 1 through 3, contained no detectable OSCS. Lots A through G and Lot J were recalled on January 17, 2008. T bars indicate standard deviations of replicate measurements. ND denotes not detected.