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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Curr Hypertens Rep. 2013 Oct;15(5):10.1007/s11906-013-0383-y. doi: 10.1007/s11906-013-0383-y

Figure 2.

Figure 2

Effects of long-term hyperglucagonaemia induced by infusion of glucagon via osmotic minipump (1 μg/h, i.p., for 4 weeks) and concurrent blockade of GCGR by [des-His1-Glu9] glucagon (5 μg/h via osmotic minipump, i.p.) on fasting blood glucose (A) and glucose tolerance (B) in glucagon-infused mice. **p<0.01 compared with basal (week 0) for fasting blood glucose (in A) or compared with 0 min for the GTT within the same group (in B). ++p<0.01, compared with glucagon-infused mice at corresponding periods. Ant, [Des-His1-Glu9]glucagon. Reprinted with permission from Li et al. [14]. Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice. Clin Sci (Lond) 2008; 114(9):591–601.