Table 1.
Correlation between miR-183 expression and clinicopathological factors of HCC.
| Factors | n | miR-183 level 2−ΔΔCT M (P25~P75) | r | P* |
|---|---|---|---|---|
| Gender | ||||
| Male | 79 | 9.178 (2.564~29.231) | −0.023 | 0.827 |
| Female | 13 | 6.431 (3.886~16.491) | ||
| Age (years) | ||||
| ≤55 | 50 | 8.415 (2.715~31.069) | −0.002 | 0.981 |
| >55 | 42 | 10.543 (2.583~23.855) | ||
| HBV | ||||
| + | 72 | 8.880 (2.687~21.728) | −0.078 | 0.887 |
| − | 20 | 10.2773 (2.646~47.116) | ||
| HCV | ||||
| + | 6 | 12.556 (0.830~99.732) | −0.002 | 0.985 |
| − | 86 | 9.015 (2.715~23.855) | ||
| Liver cirrhosis | ||||
| Yes | 86 | 9.845 (2.761~29.437) | 0.235 | 0.025 |
| No | 6 | 3.007 (1.606~4.862) | ||
| Child-Pugh score | ||||
| A | 77 | 8.583 (2.615~29.643) | 0.046 | 0.661 |
| B | 15 | 10.920 (4.737~19.942) | ||
| AFP (ng/mL) | ||||
| ≤400 | 52 | 10.525 (2.588~26.252) | −0.040 | 0.705 |
| >400 | 40 | 8.026 (2.799~28.121) | ||
| Tumor number | ||||
| 1 | 59 | 7.803 (2.961~33.794) | 0.064 | 0.544 |
| ≥2 | 33 | 10.235 (3.989~24.257) | ||
| Tumor size (cm) | ||||
| ≤3 | 12 | 8.717 (2.799~29.403) | 0.027 | 0.799 |
| >3 | 80 | 10.547 (2.223~22.574) | ||
| Vein invasion | ||||
| Yes | 25 | 9.178 (4.228~19.525) | 0.014 | 0.892 |
| No | 67 | 8.583 (1.564~33.794) | ||
| TNM grade | ||||
| I-II | 46 | 5.480 (2.381~11.794) | 0.213 | 0.042 |
| III-IV | 46 | 11.795 (4.231~33.874) | ||
| Tumor grade | ||||
| W | 22 | 4.754 (1.656~68.768) | −0.060 | 0.365 |
| M | 48 | 10.047 (3.010~28.786) | ||
| P | 22 | 7.229 (2.190~11.677) |
*The Spearman correlation coefficients were used to analyze the correlation between miR-183 expression and clinicopathological factors; P < 0.05 was considered statistically significant; W: well differentiated; M: moderately differentiated; P: poorly differentiated; HBV: hepatitis B virus; HCV: hepatitis C virus; r: correlation coefficient; TNM: tumor node metastasis; AFP: alpha-fetoprotein.