Figure 3.

ABIN1[D485N] mouse glomeruli display mesangial and subendothelial deposits. (A) TEM image of WT mouse kidney (large arrow, erythrocyte; small arrow, endothelial cell). (B) Minimal mesangial expansion and immune deposits (small arrows) in a TEM image of a 4-month-old ABIN1[D485N] mouse kidney. Podocyte foot processes are intact. The large arrow points out a monocyte in a capillary. (C) Extensive mesangial expansion and immune deposits (small arrows) in a TEM image of a 6-month-old ABIN1[D485N] mouse kidney. The large arrow points out a monocyte in a capillary. (D) Example of subendothelial immune deposits (long small arrow), areas of podocyte effacement (short small arrow), and mesangial deposits (large arrow) in a 6-month-old ABIN1[D485N] mouse kidney.