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. 2013 Aug 22;24(11):1743–1754. doi: 10.1681/ASN.2013020148

Table 1.

Glomerular, interstitial, and tubular pathology assessment in WT and ABIN1[D485N] kidneys

Variable Glomerular Size Glomerular Proliferation Mesangial Proliferation Endocapillary Proliferation Mesangial Expansion Glomerular Fibrosis Crescents Tubular Atrophy Interstitial Inflammation Interstitial Fibrosis Total Pathology Score
WT 3–6 mo 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
[D485N] 3–4 mo 1.91 (0.16)a,b 2 (0.19)a 1.73 (0.19)a 1.27 (0.27)c 1 (0.13)a 0 (0)d 0 (0)d 0 (0)d 0.55 (0.16)e 0.09 (0.09)d 8.55 (0.88)a
[D485N] 5–6 mo 2.73 (0.19)a,b/e,f 2.82 (0.18)a,e 1.82 (0.18)a,d 2.73 (0.19)a,c 2.36 (0.28)a,c 0.09 (0.09)d 0.09 (0.09)d 0.64 (0.24)d 1.55 (0.25)a,e 0.82 (0.26)d,e 15.64 (1.32)a,c

Data are mean pathologic score (SEM). The numbers were derived using a scoring system described in the Concise Methods.

a

P<0.001.

b

P values for ABIN1[D485N] versus WT mice.

c

P<0.005.

d

P=NS.

e

P<0.05.

f

P values for ABIN1[D485N] 3–4 months versus 5–6 months.