Table 1.
Glomerular, interstitial, and tubular pathology assessment in WT and ABIN1[D485N] kidneys
Variable | Glomerular Size | Glomerular Proliferation | Mesangial Proliferation | Endocapillary Proliferation | Mesangial Expansion | Glomerular Fibrosis | Crescents | Tubular Atrophy | Interstitial Inflammation | Interstitial Fibrosis | Total Pathology Score |
---|---|---|---|---|---|---|---|---|---|---|---|
WT 3–6 mo | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
[D485N] 3–4 mo | 1.91 (0.16)a,b | 2 (0.19)a | 1.73 (0.19)a | 1.27 (0.27)c | 1 (0.13)a | 0 (0)d | 0 (0)d | 0 (0)d | 0.55 (0.16)e | 0.09 (0.09)d | 8.55 (0.88)a |
[D485N] 5–6 mo | 2.73 (0.19)a,b/e,f | 2.82 (0.18)a,e | 1.82 (0.18)a,d | 2.73 (0.19)a,c | 2.36 (0.28)a,c | 0.09 (0.09)d | 0.09 (0.09)d | 0.64 (0.24)d | 1.55 (0.25)a,e | 0.82 (0.26)d,e | 15.64 (1.32)a,c |
Data are mean pathologic score (SEM). The numbers were derived using a scoring system described in the Concise Methods.
P<0.001.
P values for ABIN1[D485N] versus WT mice.
P<0.005.
P=NS.
P<0.05.
P values for ABIN1[D485N] 3–4 months versus 5–6 months.