Table 2.
Results of LEF1 and Notch2 mRNA real-time PCR analysis in tumor tissue in relation to the clinicopathologic characteristics of CRC patients and their tumors.
| Characteristic | n | LEF1, mean (SD) | P | Notch2, mean (SD) | P |
|---|---|---|---|---|---|
| Tissue type | <0.001 | <0.001 | |||
| CRC tissues | 184 | 3.7270 (1.7635) | 0.5263 (0.3320) | ||
| Paratumorous normal tissues | 184 | 0.8239 (0.2624) | 1.8675 (0.4230) | ||
| Age (years) | 0.245 | 0.292 | |||
| <60 | 72 | 3.6175 (1.5221) | 0.5613 (0.4012) | ||
| ≥60 | 112 | 3.8617 (1.1551) | 0.5038 (0.2875) | ||
| Gender | 0.879 | 0.712 | |||
| Male | 104 | 3.7410 (1.6041) | 0.5241 (0.4057) | ||
| Female | 80 | 3.7088 (1.2707) | 0.5417 (0.2362) | ||
| Tumor location | 0.611 | 0.365 | |||
| Right colon | 40 | 3.6889 (1.3662) | 0.5579 (0.2331) | ||
| Left colon | 46 | 3.5371 (1.4057) | 0.5784 (0.4124) | ||
| Rectum | 98 | 3.8317 (1.8993) | 0.4992 (0.3346) | ||
| Histology (differentiation) | 0.609 | <0.001 | |||
| Well | 86 | 3.6022 (1.9496) | 0.6760 (0.4661) | ||
| Moderate | 68 | 3.7840 (1.6342) | 0.4514 (0.2112) | ||
| Poor | 30 | 3.9557 (1.5231) | 0.3002 (0.2214) | ||
| Node metastasis | <0.001 | <0.001 | |||
| N0 | 80 | 2.2058 (1.7023) | 0.6510 (0.4138) | ||
| N1–3 | 104 | 4.8971 (1.8106) | 0.4304 (0.2691) | ||
| Distant metastasis | <0.001 | <0.001 | |||
| No | 144 | 3.1840 (1.7412) | 0.6084 (0.1059) | ||
| Yes | 40 | 5.6818 (1.8334) | 0.2557 (0.5460) | ||
| TNM stage | <0.001 | <0.001 | |||
| I | 14 | 2.1012 (1.7731) | 0.8526 (0.2113) | ||
| II | 56 | 2.9875 (1.2111) | 0.6752 (0.2547) | ||
| III | 74 | 3.3415 (1.8521) | 0.4369 (0.1821) | ||
| IV | 40 | 6.0445 (1.9694) | 0.3940 (0.6921) |