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. 2013 Oct 28;8(10):e77568. doi: 10.1371/journal.pone.0077568

Figure 3. Tc mucin inhibits cytokine production upon TCR stimulation.

Figure 3

Purified CD4+ T cells from naïve spleens were stimulated with plate bound anti-CD3 (5 µg/mL), in the presence or absence of Tc Muc (20 µg/mL). Cytokines IL-2, IL-4, IL-10, IFN-γ, TNF-α and TGF-β were detected by ELISA in the supernatants obtained after 48 h stimulation. All cytokine values in the presence of Tc Muc were significantly lower than controls (P≤0.05). Results are the means ±SD of triplicate cultures of three different experiments.