Table 3.
Top Ten Most Significant SNPs in the GWAS Results of the African Americans
| CHR | SNP | Nearest Gene | Distance (bp) | p Value in AA GWAS | p Value in Replication AA Samples | p Value in Combined AA Samples |
|---|---|---|---|---|---|---|
| Whole Cohort of African Americans | ||||||
| 8 | rs7014900 | TRPS1 | 842417 | 1.10E-06 | .45 | 1.31E-04 |
| 2 | rs13006863 | SLC4A5 | intron | 2.45E-06 | .015 | 2.25E-03 |
| 14 | rs7158872 | RPS29 | 617197 | 2.54E-06 | NT | NT |
| 11 | rs2305272 | NTM | intron | 4.70E-06 | NT | NT |
| 2 | 2-21091512 | APOB | intron | 5.07E-06 | NT | NT |
| 8 | rs16904179 | FAM49B | intron | 5.42E-06 | NT | NT |
| 11 | rs6589574 | SIK3 | intron | 8.73E-06 | NT | NT |
| 3 | rs4955793 | ZMAT3 | intron | 1.06E-05 | NT | NT |
| 7 | rs6969903 | AHR | 92683 | 1.11E-05 | NT | NT |
| 17 | rs7207499 | PRKCA | intron | 1.16E-05 | NT | NT |
| Trauma Exposed African Americans | ||||||
| 8 | rs7014900 | TRPS1 | 842417 | 1.46E-06 | .14 | 3.90E-04 |
| 11 | rs2305272 | NTM | intron | 5.22E-06 | NT | NT |
| 14 | rs7158872 | RPS29 | 617197 | 6.02E-06 | NT | NT |
| 2 | rs13006863 | SLC4A5 | intron | 6.03E-06 | .022 | 2.14E-03 |
| 6 | rs2572096 | FBXL4 | 55222 | 7.07E-06 | NT | NT |
| 8 | rs1500899 | C8orf37 | 253528 | 9.94E-06 | NT | NT |
| 2 | 2-21091512 | APOB | intron | 1.18E-05 | NT | NT |
| 21 | rs11909487 | USP25 | 40117 | 1.30E-05 | NT | NT |
| 10 | rs7076096 | GRIN1 | intron | 1.36E-05 | NT | NT |
| 16 | rs9923585 | ABCC1 | intron | 1.74E-05 | NT | NT |
AA, African Americans; bp, base pair; CHR, chromosome; GWAS, genome-wide association study; NT, not tested; SNP, single nucleotide polymorphism.