Table 2.
SNPs Evaluated for Replicated Survival Associations, the Shanghai Breast Cancer Study and the Shanghai Breast Cancer Survival Study
| Gene | SNP | Alternate Denotation (if applicable) | Gene Location 1 | Alleles 2 | Minor Allele Frequency 3
|
SBCS-I Report | |
|---|---|---|---|---|---|---|---|
| Stage 1 | Stage 2 | ||||||
| CCND1 | rs9344 | rs603965, A870G | exon 4 (S) | A/G | 43.9 | 44.9 | Shu et al, 2005 |
| COMT | rs4680 | Met158Val | exon 4 (N) | G/A | 26.4 | 26.9 | Long et al, 2007 |
| MMP7 | rs11568818 | promoter | A/G | 8.9 | 8.6 | Beeghly-Fadiel et al, 2009 | |
| MMP7 | rs11225297 | 3′ FR | A/T | 18.2 | 20.8 | Beeghly-Fadiel et al, 2009 | |
| MMP8 | rs11225395 | promoter | C/T | 38.2 | 36.7 | Decock et al, 2007 | |
| MMP12 | rs652438 | A1082G, Asn357Ser | exon 8 (M) | A/G | 10.7 | 11.2 | Shin et al, 2005 |
| PAI1/SERPINE1 | rs1799889 | 4G/5G | promoter | 4G/5G | 45.0 | 45.3 | Zhang et al, 2006 |
| TGFB1 | rs1800470 | T+29C (merged with rs1982073) | exon 1 (M) | C/T | 48.3 | 48.4 | Shu et al, 2004 |
| VEGFA | rs2010963 | G405C | 5′ UTR | G/C | 40.6 | 42.6 | Lu et al, 2005 |
1
Coding SNPs were either synonymous (S), nonsynonymous (N), or missense (M)
2
Major/minor alleles as determined by the genotype distributions among SBCS and SBCSS cases
3
Minor allele frequency among SBCS and SBCSS cases