. Author manuscript; available in PMC: 2013 Oct 28.

Published in final edited form as: J Cancer Res Clin Oncol. 2012 Feb 25;138(6):10.1007/s00432-012-1174-6. doi: 10.1007/s00432-012-1174-6

Table 4.

Joint Effect of MMP7 rs11225297 and MMP8 rs11225395 on Breast Cancer Survival, the Shanghai Breast Cancer Study and the Shanghai Breast Cancer Survival Study

MMP7 rs11225297 & MMP8 rs11225395	Overall Survival			Disease Free Survival
MMP7 rs11225297 & MMP8 rs11225395	Cases / Events	HR (95% CI) ^*	5 year % ^**	Cases / Events	HR (95% CI) ^*	5 year % ^**
Minor Alleles, N
0	249 / 68	1.0 (reference)	78.4	246 / 82	1.0 (reference)	71.6
1-2	590 / 122	0.9 (0.7-1.1)	83.9	573 / 150	0.8 (0.7-1.1)	77.6
3-4	77 / 9	0.4 (0.2-0.7)	90.0	72 / 15	0.5 (0.3-0.9)	80.1
p-value		<0.001	0.008		0.001	0.029

Cox Proportional Hazards regression, adjusted for age at diagnosis, disease stage, ER, PR, and treatment; p-value for trend

^**

Five year survival rate determined from Kaplan-Meier analysis; p-value from Log-Rank test