Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2013 Jul 2;25(5):10.1016/j.ceb.2013.06.002. doi: 10.1016/j.ceb.2013.06.002

Figure 2.

Figure 2

Examples of modes of mechanotransduction behavior, sorted by input and output types. (a) Mechanical property measurements in cells make use of assaying the passive material response to an active mechanical input [15, 16, 17•]. (b) Compression applied to cell aggregates inhibiting proliferation [27] is an example of an active mechanical input influencing an active biological output. (c) Differential adhesion governing cell sorting in aggregates is a passive, diffusion-driven behavior that occurs downstream of the passive material input of adhesive affinity [40]. (*There are no passive material responses that are directly due to stiffness.) (d) Changes in transcription factor localization is an active biological output that can occur in response to the passive mechanical input of substrate stiffness [53••].