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. 2013 Jul 16;30(4):1561–1574. doi: 10.3892/or.2013.2616

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Copyright © 2013, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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(A) Overall survival (OS) in living donor liver transplantation (LDLT) patients with hepatocellular carcinoma (HCC) according to proliferation of α-smooth muscle actin (α-SMA)-positive cancer-associated fibroblast (CAF) which was determined immunohistologically. Only one HCC recurrence patient died in 8 cases of low grade α-SMA-positive CAF group. All 4 cases of high grade α-SMA-positive CAF died due to HCC recurrence. The high grade α-SMA-positive CAF group had statistically significantly (P<0.05) poorer survival rates than the low and middle α-SMA-positive CAF groups. (B) Disease-free survival (DFS) in LDLT patients with HCC according to proliferation of α-SMA-positive CAF which was determined immunohistologically. There was only one HCC recurrence case in 8 cases of low grade α-SMA-positive CAF. All 4 cases of high grade α-SMA-positive CAF presented HCC recurrence soon after LDLT. The high grade α-SMA-positive CAF group had statistically significantly (P<0.01) poorer survival rates than the low and middle α-SMA-positive CAF groups, and middle grade α-SMA-positive CAF group had statistically significantly (P<0.05) poorer survival rates than the low grade group. There is a statistically significant correlation between post-LDLT HCC recurrence and α-SMA-positive CAF, i.e., α-SMA-positive CAF in HCC may be correlated with malignant potential of HCC progression and metastasis.

(A) Overall survival (OS) in living donor liver transplantation (LDLT) patients with hepatocellular carcinoma (HCC) according to proliferation of α-smooth muscle actin (α-SMA)-positive cancer-associated fibroblast (CAF) which was determined immunohistologically. Only one HCC recurrence patient died in 8 cases of low grade α-SMA-positive CAF group. All 4 cases of high grade α-SMA-positive CAF died due to HCC recurrence. The high grade α-SMA-positive CAF group had statistically significantly (P<0.05) poorer survival rates than the low and middle α-SMA-positive CAF groups. (B) Disease-free survival (DFS) in LDLT patients with HCC according to proliferation of α-SMA-positive CAF which was determined immunohistologically. There was only one HCC recurrence case in 8 cases of low grade α-SMA-positive CAF. All 4 cases of high grade α-SMA-positive CAF presented HCC recurrence soon after LDLT. The high grade α-SMA-positive CAF group had statistically significantly (P<0.01) poorer survival rates than the low and middle α-SMA-positive CAF groups, and middle grade α-SMA-positive CAF group had statistically significantly (P<0.05) poorer survival rates than the low grade group. There is a statistically significant correlation between post-LDLT HCC recurrence and α-SMA-positive CAF, i.e., α-SMA-positive CAF in HCC may be correlated with malignant potential of HCC progression and metastasis.