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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Surg Oncol Clin N Am. 2013 Jul 30;22(4):10.1016/j.soc.2013.06.003. doi: 10.1016/j.soc.2013.06.003

Figure 2. FAK, p53 and Mdm-2 interaction and down-stream signaling.

Figure 2

FAK binds to p53 and blocks its functions; FAK binds to Mdm-2 to facilitate p53 proteosomal degradation, as shown in [48]; Mdm-2 binds to p53 and causes its degradation. p53 activates Mdm-2 and inhibits FAK.