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. 2013 Oct 28;8(10):e78554. doi: 10.1371/journal.pone.0078554

Figure 3. Ovarian hormones protect high fat fed female mice against hyperglycemia.

Figure 3

A, Body weight in female 3xTg-AD mice was not affected by ovariectomy (OVX) in either standard or high fat groups. B, High fat diet increased abdominal retroperitoneal fat pad weight in sham-operated (solid bars) and ovariectomised (open bars) female 3xTg-AD mice equally. C, High fat diet increased fasting glucose concentrations in high fat fed female 3xTg-AD mice following ovariectomy D, Fasting insulin concentrations in sham-operated (solid bars) and ovariectomised (open bars) female 3xTg-AD mice after 4 months of feeding with either standard or high fat diet. C, Insulin resistance index, HOMA-IR. Data presented as mean ± SEM. *p<0.001 relative to regular diet fed mice; † p<0.001 relative to all other groups.